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Article

Clonal analysis in recurrent astrocytic, oligoastrocytic and oligodendroglial tumors implicates IDH1- mutation as common tumor initiating event.

PloS one - 1 Jan 2012

Lass Ulrike, Nümann Astrid, von Eckardstein Kajetan, Kiwit Jürgen, Stockhammer Florian, Horaczek Jörn A, Veelken Julian, Herold-Mende Christel, Jeuken Judith, von Deimling Andreas, Mueller Wolf

Abstract excerpt

BACKGROUND: To investigate the dynamics of inter- and intratumoral molecular alterations during tumor progression in recurrent gliomas. METHODOLOGY/PRINCIPAL FINDINGS: To address intertumoral heterogeneity we investigated non-microdissected tumor tissue of 106 gliomas representing 51 recurrent tu...

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Source

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Identifiers

PMID: 22844452
DOI: 10.1371/journal.pone.0041298
PMCID: PMC3402513

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22844452-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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