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Article

IDH-mutant astrocytoma with an evolutional progression to CDKN2A/B homozygous deletion and NTRK fusion during recurrence: A case report.

Pathology, research and practice - 1 Nov 2022

Kirishima Mari, Akahane Toshiaki, Higa Nayuta, Suzuki Shinsuke, Ueno Shinichi, Yonezawa Hajime, Uchida Hiroyuki, Hanaya Ryosuke, Yoshimoto Koji, Shimajiri Shohei, Kitazono Ikumi, Tanimoto Akihide

Abstract excerpt

We reported a case of molecularly defined isocitrate dehydrogenase (IDH)-mutant astrocytoma that recurred twice with aggressive behavior and increased anaplastic morphology. Primary and recurrent tumors were analyzed using custom-made DNA-based cancer gene and RNA-based fusion panels for next-generation sequencing (NGS). NGS analyses revealed that recurrent astrocytoma, in addition to IDH1 and tumor protein 53...

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PMID: 36265224
DOI: 10.1016/j.prp.2022.154163

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