Article
Genomic alterations of oligodendrogliomas at distant recurrence.
Cancer medicine - 1 Aug 2023
Liu Guanzheng, Bu Chaojie, Guo Guangzhong, Zhang Zhiyue, Sheng Zhiyuan, Deng Kaiyuan, Wu Shuang, Xu Sensen, Bu Yage, Gao Yushuai, Wang Meiyun, Liu Gang, Kong Lingfei, Li Tianxiao, Li Ming, Bu Xingyao
Abstract excerpt
BACKGROUND: Oligodendroglioma is known for its relatively better prognosis and responsiveness to radiotherapy and chemotherapy. However, little is known about the evolution of genetic changes as oligodendroglioma progresses. METHODS: In this study, we evaluated gene evolution invivo during tumor progression based on deep whole-genome sequencing data (ctDNA). We analyzed longitudinal genomic data from six patients...
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