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Article

Double-edged sword of inflammasome genetics in colorectal cancer prognosis.

Clinical immunology (Orlando, Fla.) - 1 Apr 2020

Cambui Raylane Adrielle Gonçalves, do Espírito Santo Gilmar Ferreira, Fernandes Fernanda Pereira, Leal Vinicius Nunes Cordeiro, Galera Bianca Borsatto, Fávaro Emerson Giuliano Palacio, Rizzo Leonardo Amorim, Elias Rosa Maria, Pontillo Alessandra

Abstract excerpt

Inflammation is a colorectal cancer (CRC) hallmark. Inflammasome-dependent cytokines IL-1ß and IL-18 can play a beneficial or detrimental role in tumorigenesis depending on cancer type. Variants in inflammasome genes were associated with tumor development and/or outcome, and have been proposed as potential biomarkers for population screening. In this study, 215 CRC patients followed-up for 10 years were examined...

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PMID: 32135277
DOI: 10.1016/j.clim.2020.108373

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