Article
Single CpG hypermethylation, allele methylation errors, and decreased expression of multiple tumor suppressor genes in normal body cells of mutation-negative early-onset and high-risk breast cancer patients.
International journal of cancer - 15 Sept 2018
Böck Julia, Appenzeller Silke, Haertle Larissa, Schneider Tamara, Gehrig Andrea, Schröder Jörg, Rost Simone, Wolf Beat, Bartram Claus R, Sutter Christian, Haaf Thomas
Abstract excerpt
To evaluate the role of constitutive epigenetic changes in normal body cells of BRCA1/BRCA2-mutation negative patients, we have developed a deep bisulfite sequencing assay targeting the promoter regions of 8 tumor suppressor (TS) genes (BRCA1, BRCA2, RAD51C, ATM, PTEN, TP53, MLH1, RB1) and the estrogene receptor gene (ESR1), which plays a role in tumor progression. We analyzed blood samples of two breast cancer...
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