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Article

MicroRNA-125b-1 accelerates a C-terminal mutant of C/EBPα (C/EBPα-C(m))-induced myeloid leukemia.

International journal of hematology - 1 Sept 2012

Enomoto Yutaka, Kitaura Jiro, Shimanuki Masaya, Kato Naoko, Nishimura Koutarou, Takahashi Mariko, Nakakuma Hideki, Kitamura Toshio, Sonoki Takashi

Abstract excerpt

MicroRNA-125b-1 (miR-125b-1) is a target of the chromosomal translocations t(11;14)(q24;q32) and t(2;11)(p21;q23), which are found in human B-lymphoid and myeloid malignancies, respectively. These translocations result in overexpression of mature miR-125b, consisting of 22 nucleotides. To analyze the role of miR-125b-1 in leukemogenesis, we created a bone marrow transplantation model using a retrovirus vector...

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Share to Bone Marrow Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CCAAT-Enhancer-Binding Protein-alpha

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Share to Leukemia, Myeloid

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Source

Identifiers

PMID: 22843432
DOI: 10.1007/s12185-012-1143-5

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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