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Chronic lymphocytic leukemia modeled in mouse by targeted <i>miR-29</i> expression

21 Jun 2010

Abstract excerpt

B-cell chronic lymphocytic leukemia (B-CLL), the most common leukemia in the Western world, occurs in two forms, aggressive (showing for the most part high ZAP-70 expression and unmutated IgH V(H)) and indolent (showing low ZAP-70 expression and mutated IgH V(H)). We found that miR-29a is up-regulated in indolent human B-CLL as compared with aggressive B-CLL and normal CD19(+) B cells. To study the role of miR-29...

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PMID: 20566844
DOI: 10.1073/pnas.1007186107

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