Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation

20 Oct 2008

Abstract excerpt

Most chromosomal translocations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) involve oncogenes that are either up-regulated or form part of new chimeric genes. The t(2;11)(p21;q23) translocation has been cloned in 19 cases of MDS and AML. In addition to this, we have shown that this translocation is associated with a strong up-regulation of miR-125b (from 6- to 90-fold). In vitro...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Advanced biosensing and bioanalysis techniques
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18936236
DOI: 10.1084/jem.20080285

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocationPMID 18936236Read ↗

MicroRNA-125b transforms myeloid cell lines by repressing multiple mRNASemantic proximity Read ↗

miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia.Semantic proximity Read ↗

MicroRNA-125b-1 accelerates a C-terminal mutant of C/EBPα (C/EBPα-C(m))-induced myeloid leukemia.Semantic proximity Read ↗

A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemiaSemantic proximity Read ↗

MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemiaSemantic proximity Read ↗

<i>MIR29B</i> regulates expression of <i>MLLT11 (AF1Q),</i> an <i>MLL</i> fusion partner, and low <i>MIR29B expression</i> associates with adverse cytogenetics and poor overall survival in AMLSemantic proximity Read ↗

MicroRNA-34b promoter hypermethylation induces CREB overexpression and contributes to myeloid transformationSemantic proximity Read ↗

Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1)Semantic proximity Read ↗

Establishment and characterization of a novel myeloid cell line from the bone marrow of a patient with the myelodysplastic syndromeSemantic proximity Read ↗

MiR‐125b inhibits cell biological progression of Ewing's sarcoma by suppressing the PI3K/Akt signalling pathwaySemantic proximity Read ↗

Altered expression pattern of miR-29a, miR-29b and the target genes in myeloid leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.