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Article

Mechanisms of BRCA1 tumor suppression.

Cancer discovery - 1 Aug 2012

Silver Daniel P, Livingston David M

Abstract excerpt

UNLABELLED: The p220 BRCA1 tumor suppressor protein has been implicated in multiple biochemical and biologic functions since its molecular cloning 18 years ago. Here, we discuss those functions most relevant for its tumor-suppressing activities with an emphasis on new findings. In particular, this review focuses on what is known of the activities of those BRCA1-binding partners that have tumor suppressor...

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Source

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Identifiers

PMID: 22843421
DOI: 10.1158/2159-8290.CD-12-0221
PMCID: PMC3437262

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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