Article
Procathepsin D expression correlates with invasive and metastatic phenotype of MDA-MB-231 derived cell lines.
International journal of biological macromolecules - 1 Jul 2007
Ohri Sujata Saraswat, Vashishta Aruna, Vetvickova Jana, Fusek Martin, Vetvicka Vaclav
Abstract excerpt
Procathepsin D (pCD) is a glycoprotein secreted abundantly by cancerous cells with a documented role in tumor development. The levels of pCD in primary tumors are highly correlated with an increased incidence of metastasis. Our earlier studies have shown that pCD exerts its effect on cancer cells through its activation peptide (AP) and involves both autocrine and paracrine modes of action. In this study, we...
Topics
- Autocrine Communication
- Breast Neoplasms
- Cathepsin D
- Cell Line, Tumor
- Enzyme Precursors
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Neoplasm Proteins
- Paracrine Communication
- Phenotype