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Article

Cathepsin D maturation and its stimulatory effect on metastasis are prevented by addition of KDEL retention signal.

Oncogene - 1 Apr 1994

Liaudet E, Garcia M, Rochefort H

Abstract excerpt

Cathepsin D is overexpressed in most primary breast cancers where its concentration is correlated with increased metastatic potential. To investigate the possible role and mechanism of this lysosomal protease in metastasis, we transfected low-metastatic rat tumor cells with wild-type human cathepsin D, or mutated forms obtained by insertion of a KDEL peptide signal responsible for ER retention, or a control KDAS...

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PMID: 8134116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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