Cathepsin D maturation and its stimulatory effect on metastasis are prevented by addition of KDEL retention signal.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Cathepsin D maturation and its stimulatory effect on metastasis are prevented by addition of KDEL retention signal.

Oncogene - 1 Apr 1994

Liaudet E, Garcia M, Rochefort H

Abstract excerpt

Cathepsin D is overexpressed in most primary breast cancers where its concentration is correlated with increased metastatic potential. To investigate the possible role and mechanism of this lysosomal protease in metastasis, we transfected low-metastatic rat tumor cells with wild-type human cathep...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cathepsin D
Endoplasmic Reticulum
Enzyme Precursors
Golgi Apparatus
Mice
Mice, Nude
Molecular Sequence Data
Mutation
Neoplasm Metastasis
Protein Sorting Signals
Rats
Receptor, IGF Type 2
Time Factors
Transfection
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8134116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8134116-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics