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Article

Reovirus replication protein μ2 influences cell tropism by promoting particle assembly within viral inclusions.

Journal of virology - 1 Oct 2012

Ooms Laura S, Jerome W Gray, Dermody Terence S, Chappell James D

Abstract excerpt

The double-stranded RNA virus mammalian reovirus displays broad cell, tissue, and host tropism. A critical checkpoint in the reovirus replication cycle resides within viral cytoplasmic inclusions, which are biosynthetic centers of genome multiplication and new-particle assembly. Replication of strain type 3 Dearing (T3) is arrested in Madin-Darby canine kidney (MDCK) cells at a step subsequent to inclusion...

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Source

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Identifiers

PMID: 22837214
DOI: 10.1128/JVI.01172-12
PMCID: PMC3457141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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