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Organelle-Like Membrane Compartmentalization of Positive-Strand RNA Virus Replication Factories

9 Sept 2010

Abstract excerpt

Positive-strand RNA virus genome replication is invariably associated with extensively rearranged intracellular membranes. Recent biochemical and electron microscopy analyses, including three-dimensional electron microscope tomographic imaging, have fundamentally advanced our understanding of the ultrastructure and function of organelle-like RNA replication factories. Notably, for a range of positive-strand RNA...

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PMID: 20825348
DOI: 10.1146/annurev.micro.112408.134012

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