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Article

Reovirus Nonstructural Protein σNS Recruits Viral RNA to Replication Organelles.

mBio - 31 Aug 2021

Lee Christopher H, Raghunathan Krishnan, Taylor Gwen M, French Andrea J, Tenorio Raquel, Fernández de Castro Isabel, Risco Cristina, Parker John S L, Dermody Terence S

Abstract excerpt

The function of the mammalian orthoreovirus (reovirus) σNS nonstructural protein is enigmatic. σNS is an RNA-binding protein that forms oligomers and enhances the stability of bound RNAs, but the mechanisms by which it contributes to reovirus replication are unknown. To determine the function of σNS-RNA binding in reovirus replication, we engineered σNS mutants deficient in RNA-binding capacity. We found that...

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Identifiers

PMID: 34225484
DOI: 10.1128/mBio.01408-21
PMCID: PMC8406312

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