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Function, Architecture, and Biogenesis of Reovirus Replication Neoorganelles

21 Mar 2019

Abstract excerpt

Most viruses that replicate in the cytoplasm of host cells form neoorganelles that serve as sites of viral genome replication and particle assembly. These highly specialized structures concentrate viral proteins and nucleic acids, prevent the activation of cell-intrinsic defenses, and coordinate the release of progeny particles. Reoviruses are common pathogens of mammals that have been linked to celiac disease...

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PMID: 30901959
DOI: 10.3390/v11030288

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