Article
Prospective evaluation of a pharmacogenetics-guided warfarin loading and maintenance dose regimen for initiation of therapy.
Blood - 15 Sept 2011
Gong Inna Y, Tirona Rommel G, Schwarz Ute I, Crown Natalie, Dresser George K, Larue Samantha, Langlois Nicole, Lazo-Langner Alejandro, Zou Guangyong, Roden Dan M, Stein C Michael, Rodger Marc, Carrier Marc, Forgie Melissa, Wells Philip S, Kim Richard B
Abstract excerpt
Single-nucleotide polymorphisms in genes that affect warfarin metabolism (cytochrome P450 2C9 gene, CYP2C9) and response (vitamin K epoxide reductase complex 1 gene, VKORC1) have an important influence on warfarin therapy, particularly during initiation; however, there is a lack of consensus regarding the optimal pharmacogenetics-based initiation strategy. We conducted a prospective cohort study in which patients...
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