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MeDIP real‐time qPCR of maternal peripheral blood reliably identifies trisomy 21

26 Jul 2012

Abstract excerpt

OBJECTIVE: To reevaluate the efficiency of the 12 differentially methylated regions (DMRs) used in the methylated DNA immunoprecipitation (MeDIP) real-time quantitative polymerase chain reaction (real-time qPCR) based approach, develop an improved version of the diagnostic formula and perform a larger validation study. METHODS: Twelve selected DMRs were checked for copy number variants in the Database of Genomic...

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PMID: 22833530
DOI: 10.1002/pd.3947

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