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Article

Non-invasive prenatal diagnosis of trisomy 21 by reverse transcriptase multiplex ligation-dependent probe amplification.

Clinical chemistry and laboratory medicine - 1 Apr 2011

Deng Yan-Hua, Yin Ai-Hua, He Qiong, Chen Jia-Chang, He Yun-Shao, Wang Hua-Qiao, Li Ming, Chen Hua-Yun

Abstract excerpt

BACKGROUND: Obtaining fetal DNA or RNA by either chorionic villus sampling (CVS) or amniocentesis is currently, the gold standard prenatal diagnosis. However, these invasive procedures carry risk of miscarriage. A reliable method for non-invasive prenatal diagnosis (NIPD) has long been sought to reduce the risk of miscarriage. METHODS: Cell-free fetal RNA was extracted from the plasma of peripheral blood from 121...

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PMID: 21303301
DOI: 10.1515/CCLM.2011.099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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