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Selection and evaluation of DNase I hypersensitive sites for prenatal screening of trisomy 21 in the fetus

24 Jul 2026

Abstract excerpt

This study introduces a novel approach for noninvasive prenatal testing (NIPT) of chromosomal abnormalities, based on analysis of epigenetic features in circulating cell-free DNA (cfDNA). The core innovation of our method leverages fundamental differences in chromatin organization between maternal and fetal cells. Specifically, we focused on genomic regions that exhibit open chromatin configuration in maternal...

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Share to Epigenetics and DNA Methylation
Share to Genomic variations and chromosomal abnormalities
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42499385
DOI: 10.18699/vjgb-26-67

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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