Article
Synergy of total PLAC4 RNA concentration and measurement of the RNA single-nucleotide polymorphism allelic ratio for the noninvasive prenatal detection of trisomy 21.
Clinical chemistry - 1 Jan 2010
Tsui Nancy B Y, Akolekar Ranjit, Chiu Rossa W K, Chow Katherine C K, Leung Tak Y, Lau Tze K, Nicolaides Kypros H, Lo Y M Dennis
Abstract excerpt
BACKGROUND: Maternal plasma mRNA encoded by the PLAC4 gene (placenta-specific 4), which is transcribed from chromosome 21 in placental cells, is a potential marker for the noninvasive assessment of chromosome 21 dosage in the fetus. We evaluated the diagnostic sensitivities and specificities of 2 trisomy 21-screening approaches that use maternal plasma PLAC4 mRNA. METHODS: We studied maternal plasma samples from...
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