Article
Genetic and epigenetic analysis of the beta-2-microglobulin gene in microsatellite instable colorectal cancer.
Clinical and experimental medicine - 1 Feb 2020
Snahnicanova Zuzana, Kasubova Ivana, Kalman Michal, Grendar Marian, Mikolajcik Peter, Gabonova Eva, Laca Ludovit, Caprnda Martin, Rodrigo Luis, Ciccocioppo Rachele, Kruzliak Peter, Plank Lukas, Lasabova Zora
Abstract excerpt
One of the most common mechanisms of immune evasion in MSI colorectal cancers (CRCs) is loss of HLA class I expression due to mutations in B2M gene which can become a negative predictor for checkpoint blockade therapy. The aim of this study was the determination of prevalence of B2M somatic mutations in MSI CRC patients and relationship between B2M mutations and lymphocytes infiltration and other...
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