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Article

Beta2-microglobulin mutations in microsatellite unstable colorectal tumors.

International journal of cancer - 15 Jul 2007

Kloor Matthias, Michel Sara, Buckowitz Boris, Rüschoff Josef, Büttner Reinhard, Holinski-Feder Elke, Dippold Wolfgang, Wagner Rudolf, Tariverdian Mirjam, Benner Axel, Schwitalle Yvette, Kuchenbuch Beate, von Knebel Doeberitz Magnus

Abstract excerpt

Defects of DNA mismatch repair (MMR) cause the high level microsatellite instability (MSI-H) phenotype. MSI-H cancers may develop either sporadically or in the context of the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome that is caused by germline mutations of MMR genes. In colorectal cancer (CRC), MSI-H is characterized by a dense lymphocytic infiltration, reflecting a high immunogenicity of these...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17373663
DOI: 10.1002/ijc.22691

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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