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Article

Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability.

Translational psychiatry - 6 Mar 2012

Shumay E, Fowler J S, Wang G-J, Logan J, Alia-Klein N, Goldstein R Z, Maloney T, Wong C, Volkow N D

Abstract excerpt

Low dopamine D2 receptor (D2R) levels in the striatum are consistently reported in cocaine abusers; inter-individual variations in the degree of the decrease suggest a modulating effect of genetic makeup on vulnerability to addiction. The PER2 (Period 2) gene belongs to the clock genes family of circadian regulators; circadian oscillations of PER2 expression in the striatum was modulated by dopamine through D2Rs....

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Identifiers

PMID: 22832851
DOI: 10.1038/tp.2012.11
PMCID: PMC3309530

Genes

PER2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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