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Article

Underlying Susceptibility to Eating Disorders and Drug Abuse: Genetic and Pharmacological Aspects of Dopamine D4 Receptors.

Nutrients - 30 Jul 2020

Botticelli Luca, Micioni Di Bonaventura Emanuela, Del Bello Fabio, Giorgioni Gianfabio, Piergentili Alessandro, Romano Adele, Quaglia Wilma, Cifani Carlo, Micioni Di Bonaventura Maria Vittoria

Abstract excerpt

The dopamine D4 receptor (DRD4) has a predominant expression in the prefrontal cortex (PFC), brain area strictly involved in the modulation of reward processes related to both food and drug consumption. Additionally, the human DRD4 gene is characterized by a variable number of tandem repeats (VNTR) in the exon 3 and, among the polymorphic variants, the 7-repeat (7R) allele appears as a contributing factor in the...

Topics

Alleles
Animals
Brain
Dopamine
Exons
Feeding and Eating Disorders
Genetic Predisposition to Disease
Humans
Minisatellite Repeats
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Dopamine D4

Substance-Related Disorders

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Open in PubMed Open full text

Identifiers

PMID: 32751662
DOI: 10.3390/nu12082288
PMCID: PMC7468707

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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