Article
Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Mar 2011
Moyer Robert A, Wang Danxin, Papp Audrey C, Smith Ryan M, Duque Linda, Mash Deborah C, Sadee Wolfgang
Abstract excerpt
The dopamine receptor D2 (encoded by DRD2) is implicated in susceptibility to mental disorders and cocaine abuse, but mechanisms responsible for this relationship remain uncertain. DRD2 mRNA exists in two main splice isoforms with distinct functions: D2 long (D2L) and D2 short (D2S, lacking exon 6), expressed mainly postsynaptically and presynaptically, respectively. Two intronic single-nucleotide polymorphisms...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.