Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody.

doi:10.1089/thy.2007.0034

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Article

Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody.

Thyroid : official journal of the American Thyroid Association - 1 May 2007

Sanders Jane, Chirgadze Dimitri Y, Sanders Paul, Baker Stuart, Sullivan Andrew, Bhardwaja Anshu, Bolton Jane, Reeve Magnus, Nakatake Nobuhiro, Evans Michele, Richards Tonya, Powell Michael, Miguel Ricardo Núñez, Blundell Tom L, Furmaniak Jadwiga, Smith Bernard Rees

Abstract excerpt

OBJECTIVE: To analyze interactions between the thyroid-stimulating hormone receptor (TSHR) and a thyroid-stimulating human monoclonal autoantibody (M22) at the molecular level. DESIGN: A complex of part of the TSHR extracellular domain (amino acids 1-260; TSHR260) bound to M22 Fab was prepared and purified. Crystals suitable for X-ray diffraction analysis were obtained and the structure solved at 2.55 A...

Topics

Amino Acid Sequence
Animals
CHO Cells
Cricetinae
Cricetulus
Crystallization
Follicle Stimulating Hormone
Humans
Immunoglobulin Fab Fragments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulins, Thyroid-Stimulating

Molecular Sequence Data

Mutation

Receptors, FSH

Receptors, Thyrotropin

X-Ray Diffraction

Source

Open in PubMed

Identifiers

PMID: 17542669
DOI: 10.1089/thy.2007.0034

Genes

TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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