Article
Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development.
Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 2003
Moulson Casey L, Martin Daniel R, Lugus Jesse J, Schaffer Jean E, Lind Anne C, Miner Jeffrey H
Abstract excerpt
Wrinkle-free (wrfr) is a previously uncharacterized, spontaneous, autosomal recessive mouse mutation resulting in very tight, thick skin. wrfr mutant mice exhibit severe breathing difficulties secondary to their tight skin and die shortly after birth. This phenotype is strikingly similar to a very rare human genetic disorder, restrictive dermopathy. wrfr mutant mice display a defective skin barrier, which is...
Topics
Join the communities discussing this publication.