Article
Two very long chain fatty acid acyl-CoA synthetase genes, acs-20 and acs-22, have roles in the cuticle surface barrier in Caenorhabditis elegans.
PloS one - 25 Jan 2010
Kage-Nakadai Eriko, Kobuna Hiroyuki, Kimura Masako, Gengyo-Ando Keiko, Inoue Takao, Arai Hiroyuki, Mitani Shohei
Abstract excerpt
In multicellular organisms, the surface barrier is essential for maintaining the internal environment. In mammals, the barrier is the stratum corneum. Fatty acid transport protein 4 (FATP4) is a key factor involved in forming the stratum corneum barrier. Mice lacking Fatp4 display early neonatal lethality with features such as tight, thick, and shiny skin, and a defective skin barrier. These symptoms are...
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