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Article

Dynamics of major histocompatibility complex class I association with the human peptide-loading complex.

The Journal of biological chemistry - 7 Sept 2012

Panter Michaela S, Jain Ankur, Leonhardt Ralf M, Ha Taekjip, Cresswell Peter

Abstract excerpt

Although the human peptide-loading complex (PLC) is required for optimal major histocompatibility complex class I (MHC I) antigen presentation, its composition is still incompletely understood. The ratio of the transporter associated with antigen processing (TAP) and MHC I to tapasin, which is responsible for MHC I recruitment and peptide binding optimization, is particularly critical for modeling of the PLC....

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Identifiers

PMID: 22829594
DOI: 10.1074/jbc.M112.387704
PMCID: PMC3438949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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