Article
Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia.
The Lancet. Oncology - 1 Feb 2009
Coustan-Smith Elaine, Mullighan Charles G, Onciu Mihaela, Behm Frederick G, Raimondi Susana C, Pei Deqing, Cheng Cheng, Su Xiaoping, Rubnitz Jeffrey E, Basso Giuseppe, Biondi Andrea, Pui Ching-Hon, Downing James R, Campana Dario
Abstract excerpt
BACKGROUND: About a fifth of children with acute T-lymphoblastic leukaemia (T-ALL) succumb to the disease, suggesting an unrecognised biological heterogeneity that might contribute to drug resistance. We postulated that T-ALL originating from early T-cell precursors (ETPs), a recently defined subset of thymocytes that retain stem-cell-like features, would respond poorly to lymphoid-cell-directed therapy. We...
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