Article
FLT3 mutations in early T-cell precursor ALL characterize a stem cell like leukemia and imply the clinical use of tyrosine kinase inhibitors.
PloS one - 1 Jan 2013
Neumann Martin, Coskun Ebru, Fransecky Lars, Mochmann Liliana H, Bartram Isabelle, Sartangi Nasrin Farhadi, Heesch Sandra, Gökbuget Nicola, Schwartz Stefan, Brandts Christian, Schlee Cornelia, Haas Rainer, Dührsen Ulrich, Griesshammer Martin, Döhner Hartmut, Ehninger Gerhard, Burmeister Thomas, Blau Olga, Thiel Eckhard, Hoelzer Dieter, Hofmann Wolf-Karsten, Baldus Claudia D
Abstract excerpt
Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) has been identified as high-risk subgroup of acute T-lymphoblastic leukemia (T-ALL) with a high rate of FLT3-mutations in adults. To unravel the underlying pathomechanisms and the clinical course we assessed molecular alterations and clinical characteristics in a large cohort of ETP-ALL (n = 68) in comparison to non-ETP T-ALL adult patients....
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