Relationship of immunohistochemistry, copy number aberrations and epigenetic disorders with BRCAness pattern in hereditary and sporadic breast cancer.

doi:10.1007/s10689-015-9864-2

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Article

Relationship of immunohistochemistry, copy number aberrations and epigenetic disorders with BRCAness pattern in hereditary and sporadic breast cancer.

Familial cancer - 1 Apr 2016

Murria Estal Rosa, Palanca Suela Sarai, de Juan Jiménez Inmaculada, Alenda Gonzalez Cristina, Egoavil Rojas Cecilia, García-Casado Zaida, López Guerrero Jose Antonio, Juan Fita María José, Sánchez Heras Ana Beatriz, Segura Huerta Ángel, Santaballa Bertrán Ana, Chirivella González Isabel, Llop García Marta, Pérez Simó Gema, Barragán González Eva, Bolufer Gilabert Pascual

Abstract excerpt

The study aims to identify the relevance of immunohistochemistry (IHC), copy number aberrations (CNA) and epigenetic disorders in BRCAness breast cancers (BCs). We studied 95 paraffin included BCs, of which 41 carried BRCA1/BRCA2 germline mutations and 54 were non hereditary (BRCAX/Sporadic). Samples were assessed for BRCA1ness and CNAs by Multiplex Ligation-dependent Probe Amplification (MLPA); promoter...

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Identifiers

PMID: 26723934
DOI: 10.1007/s10689-015-9864-2

Genes

APC
MYC
BRCA1
ATM
BRCA2
EGFR
RASSF1

Provenance

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