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Computational modeling of protracted HCMV replication using genome substrates and protein temporal profiles

22 Aug 2022

Abstract excerpt

Human cytomegalovirus (HCMV) is a major cause of illness in immunocompromised individuals. The HCMV lytic cycle contributes to the clinical manifestations of infection. The lytic cycle occurs over ∼96 h in diverse cell types and consists of viral DNA (vDNA) genome replication and temporally distinct expression of hundreds of viral proteins. Given its complexity, understanding this elaborate system can be...

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PMID: 35994667
DOI: 10.1073/pnas.2201787119

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