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Article

Genetic variants affecting mitochondrial function provide further insights for kidney disease.

BMC genomics - 10 Jun 2024

Cañadas-Garre Marisa, Baños-Jaime Blanca, Maqueda Joaquín J, Smyth Laura J, Cappa Ruaidhri, Skelly Ryan, Hill Claire, Brennan Eoin P, Doyle Ross, Godson Catherine, Maxwell Alexander P, McKnight Amy Jayne

Abstract excerpt

BACKGROUND: Chronic kidney disease (CKD) is a complex disorder that has become a high prevalence global health problem, with diabetes being its predominant pathophysiologic driver. Autosomal genetic variation only explains some of the predisposition to kidney disease. Variations in the mitochondrial genome (mtDNA) and nuclear-encoded mitochondrial genes (NEMG) are implicated in susceptibility to kidney disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Mitochondrial

Share to Genetic Variation

Share to Glomerular Filtration Rate

Share to Haplotypes

Share to Mitochondria

Share to Renal Insufficiency, Chronic

Source

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Identifiers

PMID: 38858654
DOI: 10.1186/s12864-024-10449-1
PMCID: PMC11163707

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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