Article
Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine.
Immunity - 23 Nov 2011
Lewis Kanako L, Caton Michele L, Bogunovic Milena, Greter Melanie, Grajkowska Lucja T, Ng Dennis, Klinakis Apostolos, Charo Israel F, Jung Steffen, Gommerman Jennifer L, Ivanov Ivaylo I, Liu Kang, Merad Miriam, Reizis Boris
Abstract excerpt
Dendritic cells (DCs) in tissues and lymphoid organs comprise distinct functional subsets that differentiate in situ from circulating progenitors. Tissue-specific signals that regulate DC subset differentiation are poorly understood. We report that DC-specific deletion of the Notch2 receptor caused a reduction of DC populations in the spleen. Within the splenic CD11b(+) DC subset, Notch signaling blockade ablated...
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