Article
Upregulation of CREB-mediated transcription enhances both short- and long-term memory.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jun 2011
Suzuki Akinobu, Fukushima Hotaka, Mukawa Takuya, Toyoda Hiroki, Wu Long-Jun, Zhao Ming-Gao, Xu Hui, Shang Yuze, Endoh Kengo, Iwamoto Taku, Mamiya Nori, Okano Emiko, Hasegawa Shunsuke, Mercaldo Valentina, Zhang Yue, Maeda Ryouta, Ohta Miho, Josselyn Sheena A, Zhuo Min, Kida Satoshi
Abstract excerpt
Unraveling the mechanisms by which the molecular manipulation of genes of interest enhances cognitive function is important to establish genetic therapies for cognitive disorders. Although CREB is thought to positively regulate formation of long-term memory (LTM), gain-of-function effects of CREB remain poorly understood, especially at the behavioral level. To address this, we generated four lines of transgenic...
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