Article

Genetic and behavioural requirements for structural brain plasticity

2018-10-03

Abstract excerpt

1 Human MRI studies show that experience can lead to changes in the volume of task-specific brain regions; however, the behavioural and molecular processes driving these changes remain poorly understood. Here, we used in-vivo mouse MRI and RNA sequencing to investigate the neuroanatomical and transcriptional changes induced by environmental enrichment, exercise, and social interaction. Additionally, we asked wheth...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fdfd6591-599a-58ab-a030-1af30bf51417
DOI: 10.1101/431999

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic and behavioural requirements for structural brain plasticityDOI 10.1101/431999Read

Environmental enrichment alters locomotor behaviour and ventricular volume in Mecp2 1lox mice.Semantic proximity Read

Spatial gene expression analysis of neuroanatomical differences in mouse models.Semantic proximity Read

Brain Structure and Working Memory Adaptations Associated with Maturation and Aging in MiceSemantic proximity Read

Mouse MRI shows brain areas larger in males emerge earlier than those larger in femalesSemantic proximity Read

Mouse MRI shows brain areas relatively larger in males emerge before those larger in femalesSemantic proximity Read

A single-cell transcriptomic analysis of the mouse hippocampus after voluntary exerciseSemantic proximity Read

Alterations of brain anatomy in mouse model of MDD created by replacement of homologous mouse DNA sequence with an illness-associated 6-base human CREB1 promoter sequence.Semantic proximity Read

Effects of environmental enrichment on gene expression in the brainSemantic proximity Read

CREB selectively controls learning-induced structural remodeling of neurons.Semantic proximity Read

Affective dysfunction in a mouse model of Rett syndrome: Therapeutic effects of environmental stimulation and physical activity.Semantic proximity Read

Neuroanatomy in mouse models of Rett syndrome is related to the severity of Mecp2 mutation and behavioral phenotypes.Semantic proximity Read

Structural alterations in the amygdala and impaired social incentive learning in a mouse model of a genetic variant associated with neurodevelopmental disordersSemantic proximity Read