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Article

Relation of the multilocus genetic composite reflecting high dopamine signaling capacity to future increases in BMI.

Appetite - 1 Apr 2015

Yokum Sonja, Marti C Nathan, Smolen Andrew, Stice Eric

Abstract excerpt

Because food intake exerts its rewarding effect by increasing dopamine (DA) signaling in reward circuitry, it theoretically follows that individuals with a greater number of genotypes putatively associated with high DA signaling capacity are at increased risk for overeating and subsequent weight gain. We tested the association between the multilocus genetic composite risk score, defined by the total number of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25523644
DOI: 10.1016/j.appet.2014.12.202
PMCID: PMC4333052

Genes

COMT
DRD2
DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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