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Article

Functional Genetic Variation in Dopamine Signaling Moderates Prefrontal Cortical Activity During Risky Decision Making.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Feb 2016

Kohno Milky, Nurmi Erika L, Laughlin Christopher P, Morales Angelica M, Gail Emma H, Hellemann Gerhard S, London Edythe D

Abstract excerpt

Brain imaging has revealed links between prefrontal activity during risky decision-making and striatal dopamine receptors. Specifically, striatal dopamine D2-like receptor availability is correlated with risk-taking behavior and sensitivity of prefrontal activation to risk in the Balloon Analogue Risk Task (BART). The extent to which these associations, involving a single neurochemical measure, reflect more...

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Source

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Identifiers

PMID: 26119471
DOI: 10.1038/npp.2015.192
PMCID: PMC4707816

Genes

COMT
DRD2
DRD3
DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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