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Specification of a dopaminergic phenotype from adult human mesenchymal stem cells.

Stem cells (Dayton, Ohio) - 1 Nov 2007

Trzaska Katarzyna A, Kuzhikandathil Eldo V, Rameshwar Pranela

Abstract excerpt

Dopamine (DA) neurons derived from stem cells are a valuable source for cell replacement therapy in Parkinson disease, to study the molecular mechanisms of DA neuron development, and for screening pharmaceutical compounds that target DA disorders. Compared with other stem cells, MSCs derived from the adult human bone marrow (BM) have significant advantages and greater potential for immediate clinical application....

Topics

Adolescent
Adult
Cell Differentiation
Cells, Cultured
Dopamine
Flow Cytometry
Genetic Markers
Humans
Mesenchymal Stem Cells
Phenotype
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17656644
DOI: 10.1634/stemcells.2007-0212

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