Article

Generation of disease-relevant neurons from human pluripotent stem cells

2013-01-01

Abstract excerpt

This thesis describes investigations into exogenous factors that influence fate-choices during human pluripotent stem cell (PSC) differentiation in vitro. I describe novel growth factor environments and small molecule regimes that provide patterning signals enabling directed differentiation of human PSCs towards biomedically relevant neurons. I provide evidence that the TGFβ growth factor Activin can promote ventr...

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Literature Corpus work: b55c081f-d70f-53f1-948e-732bc0e9c5b3
DOI: 10.25560/14670

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