Article
Mesangial cell integrin αvβ8 provides glomerular endothelial cell cytoprotection by sequestering TGF-β and regulating PECAM-1.
The American journal of pathology - 1 Feb 2011
Khan Shenaz, Lakhe-Reddy Sujata, McCarty Joseph H, Sorenson Christine M, Sheibani Nader, Reichardt Louis F, Kim Jane H, Wang Bingcheng, Sedor John R, Schelling Jeffrey R
Abstract excerpt
Integrins are heterodimeric receptors that regulate cell adhesion, migration, and apoptosis. Integrin αvβ8 is most abundantly expressed in kidney and brain, and its major ligand is latent transforming growth factor-β (TGF-β). Kidney αvβ8 localizes to mesangial cells, which appose glomerular endothelial cells and maintain glomerular capillary structure by mechanical and poorly understood paracrine mechanisms. To...
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