Article
GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers.
PLoS genetics - 1 Jan 2012
Li Shengping, Qian Ji, Yang Yuan, Zhao Wanting, Dai Juncheng, Bei Jin-Xin, Foo Jia Nee, McLaren Paul J, Li Zhiqiang, Yang Jingmin, Shen Feng, Liu Li, Yang Jiamei, Li Shuhong, Pan Shandong, Wang Yi, Li Wenjin, Zhai Xiangjun, Zhou Boping, Shi Lehua, Chen Xinchun, Chu Minjie, Yan Yiqun, Wang Jun, Cheng Shuqun, Shen Jiawei, Jia Weihua, Liu Jibin, Yang Jiahe, Wen Zujia, Li Aijun, Zhang Ying, Zhang Guoliang, Luo Xianrong, Qin Hongbo, Chen Minshan, Wang Hua, Jin Li, Lin Dongxin, Shen Hongbing, He Lin, de Bakker Paul I W, Wang Hongyang, Zeng Yi-Xin, Wu Mengchao, Hu Zhibin, Shi Yongyong, Liu Jianjun, Zhou Weiping
Abstract excerpt
Genome-wide association studies (GWAS) have recently identified KIF1B as susceptibility locus for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). To further identify novel susceptibility loci associated with HBV-related HCC and replicate the previously reported association, we performed a large three-stage GWAS in the Han Chinese population. 523,663 autosomal SNPs in 1,538 HBV-positive HCC...
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