Article
A genome-wide association study with DNA pooling identifies the variant rs11866328 in the GRIN2A gene that affects disease progression of chronic HBV infection.
Viral immunology - 1 Oct 2011
Liu Lifeng, Li Jin, Yao Jinjian, Yu Jinling, Zhang Jinliang, Ning Qin, Wen Zirong, Yang Daguo, He Yongwen, Kong Xinjuan, Song Qilong, Chen Man, Yang Hong, Liu Qing, Li Senlin, Lin Jusheng
Abstract excerpt
Host genetics play a vital role in determining clinical outcomes of hepatitis B virus (HBV) infection. To identify novel susceptibility loci to HBV progression, we carried out a genome-wide association study with DNA pooling. This study assessed the relationship between 8 highly-ranked SNPs selected from our DNA pool and disease progression of HBV infection in two independent case-control studies. The first...
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