Article
Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers.
Nature genetics - 1 Sept 2010
Zhang Hongxing, Zhai Yun, Hu Zhibin, Wu Chen, Qian Ji, Jia Weihua, Ma Fuchao, Huang Wenfeng, Yu Lixia, Yue Wei, Wang Zhifu, Li Peiyao, Zhang Yang, Liang Renxiang, Wei Zhongliang, Cui Ying, Xie Weimin, Cai Mi, Yu Xinsen, Yuan Yunfei, Xia Xia, Zhang Xiumei, Yang Hao, Qiu Wei, Yang Jingmin, Gong Feng, Chen Minshan, Shen Hongbing, Lin Dongxin, Zeng Yi-Xin, He Fuchu, Zhou Gangqiao
Abstract excerpt
To identify susceptibility variants for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), we conducted a genome-wide association study by genotyping 440,794 SNPs in 355 chronic HBV carriers with HCC and 360 chronic HBV carriers without HCC, all of Chinese ancestry. We identified one intronic SNP (rs17401966) in KIF1B on chromosome 1p36.22 that was highly associated with HBV-related HCC and confirmed...
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