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Article

Assessment of NMDA receptor NR1 subunit hypofunction in mice as a model for schizophrenia.

Genes, brain, and behavior - 1 Oct 2009

Halene T B, Ehrlichman R S, Liang Y, Christian E P, Jonak G J, Gur T L, Blendy J A, Dow H C, Brodkin E S, Schneider F, Gur R C, Siegel S J

Abstract excerpt

N-methyl-D-aspartate receptors (NMDARs) play a pivotal role in excitatory neurotransmission, synaptic plasticity and brain development. Clinical and experimental evidence suggests a dysregulation of NMDAR function and glutamatergic pathways in the pathophysiology of schizophrenia. We evaluated electrophysiological and behavioral properties of NMDAR deficiency utilizing mice that express only 5-10% of the normal...

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Identifiers

PMID: 19563516
DOI: 10.1111/j.1601-183X.2009.00504.x
PMCID: PMC2757454

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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