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Article

Tangle diseases and the tau haplotypes.

Alzheimer disease and associated disorders - 1 Jan 2000

Hardy John, Pittman Alan, Myers Amanda, Fung Hon Chung, de Silva Rohan, Duckworth Jaime

Abstract excerpt

Neurofibrillary tangles are found in many neurologic diseases. Here we review the unusual characteristics of the MAPT locus, which shows genetic association with many of these diseases and in Caucasian populations, is the largest stretch of linkage disequilibrium in the genome. We discuss the reason for this disequilibrium, its evolutionary history, and the role of genetic variability at MAPT in the etiology of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16493238
DOI: 10.1097/01.wad.0000201853.54493.d8

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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