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Article

Identification of two novel phenotypically distinct breast cancer cell subsets based on Sox2 transcription activity.

Cellular signalling - 1 Nov 2012

Wu Fang, Zhang Jingdong, Wang Peng, Ye Xiaoxia, Jung Karen, Bone Kathleen M, Pearson Joel D, Ingham Robert J, McMullen Todd P, Ma Yupo, Lai Raymond

Abstract excerpt

Sox2 (sex-determining region Y-box protein 2) is a transcription factor regulating pluripotency in embryonic stem cells. Sox2 is aberrantly expressed in breast and other cancers, though its biological significance remains widely unexplored. To understand the significance of this aberrancy, we assessed the transcription activity of Sox2 in two Sox2-expressing breast cancer cell lines, MCF7 and ZR751, using a...

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Identifiers

PMID: 22800865
DOI: 10.1016/j.cellsig.2012.07.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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