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Cervical Cancer Cells with Positive Sox2 Expression Exhibit the Properties of Cancer Stem Cells

28 Jan 2014

Abstract excerpt

BACKGROUND: Although Sox2 expression has been found in several types of cancer, it has not yet been used to identify or isolate CSCs in somatic carcinoma. METHODS: SiHa and C33A cells stably transfected with a plasmid containing human Sox2 transcriptional elements driving the enhanced green fluorescent protein (EGFP) reporter were sorted into the Sox2-positive and the Sox2-negative populations by FACS, and Sox2...

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PMID: 24489842
DOI: 10.1371/journal.pone.0087092

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