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Article

YB-1 regulates Sox2 to coordinately sustain stemness and tumorigenic properties in a phenotypically distinct subset of breast cancer cells.

BMC cancer - 9 May 2014

Jung Karen, Wu Fang, Wang Peng, Ye Xiaoxia, Abdulkarim Bassam S, Lai Raymond

Abstract excerpt

BACKGROUND: Sox2, a transcription factor and an embryonic stem cell marker, has been implicated in the pathogenesis of breast cancer (BC). YB-1 is another transcription factor that has been shown to promote stemness in BC cells. METHODS: Western blotting, quantitative PCR, and siRNAs were used to query the regulatory relationships between YB-1, Sox2, and their downstream targets. Chromatin immunoprecipitation was...

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Identifiers

PMID: 24885403
DOI: 10.1186/1471-2407-14-328
PMCID: PMC4025193

Genes

CCND1
ITGA6
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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